6 April, 2016
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.(HJF) is seeking a Postdoctoral Fellow for the Department of Medicine, Uniformed Services University of the Health Sciences (USUHS) located in Bethesda, Maryland. HJF provides scientific, technical and programmatic support services to USUHS.
A postdoctoral position is open in the Department of Medicine, Uniformed Services University of the Health Sciences (USU) in Bethesda, MD to investigate cellular mechanisms leading to the development of anti-drug antibodies versus functional immune tolerance to a therapeutic protein, coagulation factor VIII. Peripheral blood mononuclear cells and CD4 T cells from hemophilia A subjects will be characterized by immunophenotyping (ELISPOTs, flow cytometry, etc.) and RNAseq, transcriptomics and bioinformatics analysis. Antigen-specific T cells will be isolated and TCR repertoires characterized and correlated with clinical profiles.
The ideal candidate will have a strong background in immunology and/or analysis of high throughput genomic data, including but not limited to standard immunophenotyping methods, single cell (or clonal) RNA-Seq data analysis, and translational bioinformatics. This position is funded under the Collaborative Health Initiatives Research Program, a joint USU/NHLBI research initiative. Our lab works closely with the rapidly expanding USU Genomics and Bioinformatics Core facilities, providing an opportunity to receive training and apply cutting-edge genomic technologies in a highly collaborative environment.
Additional relevant skills: Experience in clinical and preclinical research, IRB protocol development and study coordination, statistical analysis of experimental data.
Ph.D. in Immunology, Bioinformatics, or a related field. Excellent communications skills in English (both verbal and written) and demonstration of research productivity through publication record.
* Assists in designing, developing, executing, and implementing scientific research
* Performs specialized laboratory research utilizing experimental protocols which will involve specialized procedures such as isolation of PBMCs, RNA and DNA from human blood samples, generation of cDNA libraries, analysis of transcriptomics data, TCR repertoire analysis, and immunophenotyping by flow and ELISPOT analysis
* Collects and handles samples and keeps detailed records of experiments
* Assists with the preparation of data for presentations at scientific meetings and for publication in journals
* Assists with training laboratory staff as needed
* Maintains cleanliness of laboratory areas
* Performs other duties as assigned
* Required Knowledge, Skills, and Abilities: Solid knowledge of immunology and/or analysis of transcriptomics and TCR repertoire data; ability to analyze and interpret data; eagerness to learn and apply new techniques
* Minimum Education/Training Requirements: PhD in a related scientific discipline
* Minimum Experience: None
* Physical Capabilities: Long periods of standing and sitting; intricate work with hands; carrying of light and moderately heavy laboratory equipment
* Supervisory Responsibilities/Controls: May provide guidance to laboratory staff
* Work Environment: Laboratory environment; may involve working with biohazardous materials; may require working evenings and weekends
HOW TO APPLY:
Please apply on-line at http://www.hjf.org/careers Click “Advanced Search” and enter job number 211314 in the Job Opening ID box.
HJF is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.
This post is not valid after Sunday June 5th, 2016