Molecular Biology of Cancer and Bioinformatics

Molecular Biology of Cancer and Bioinformatics

The Mitsiades Lab has positions available for motivated postdoctoral research fellows in the integrative analysis of genomic, epigenomic, transcriptomic, and proteomic large scale datasets and analysis of cancer. The positions provide exciting opportunities in a research program in the multi-‘omics’ integrative analysis of prostate cancer and breast cancer and the mechanisms involved in their hormonal regulation (Proc Natl Acad Sci U S A. 2013;110(17):6997-7002, PMID: 23559371; Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18261-6, PMID: 25489091; Cancer Res 2012;72(23):6142-52, PMID: 22971343; Cancer Res 2013;73(15):4599–605, PMID: 23887973; Cancer Res. 2014;74(19):5631-43, PMID: 25274033; Oncogene 2016, PMID: 26364608; Oncogene 2017, PMID: 28414305).  The Mitsiades lab collaborates extensively with several other research groups, both locally and nationally.

and opportunities: Baylor College of Medicine is a pioneer in the field of gene regulation, steroid receptors and their transcriptional coactivators, providing a rich scientific environment with many unique and unparalleled opportunities for collaborative research.

Bioinformatic position: The successful candidate will be expected to participate in multiple projects involving integration of high-volume data sets, design and implementation of data processing pipelines, and analyses of proteomic and epigenomic data. The ideal candidate will have a Ph.D, a strong background in , and either a degree in biology or at least two years of experience in .  Experience with statistical analysis tools such as R or Matlab, the UNIX/Linux cluster computing using PBS, and scripting languages such as Ruby, Perl, or Python is strongly recommended. Due to the nature of the position, the candidate must have excellent written and verbal English skills, strong communication and interpersonal skills, and be capable of working with large collaborative teams. Tools developed during the course of collaborative projects will be made available via web services such as the Galaxy server. The candidate must have experience in analysis of massively parallel sequencing data and/or data, and be familiar with widely used genomic databases and software.

Wet lab position: Highly motivated individuals with PhD in molecular biology, with a demonstrated competence and experience in the biology of cancer, preferably prostate or breast cancer and/or steroid receptors (androgen receptor, estrogen receptor) and/or protein ubiquitination and publications in internationally recognized journals. Technical expertise in standard basic molecular and cellular techniques, including cell culture, transfections/transductions, siRNA, molecular cloning, plasmid isolation, etc is required. Experience on protein ubiquitination studies and/or animal studies is highly desirable. Candidates must be enthusiastic, self-motivated, dedicated to science and problem solving, with organizational skills and effective at working independently and leading projects, while also collaborating and assisting the team in its collective research goals. Attention to detail and ability to work on multiple projects is expected. Applicants should be fluent in English and available for an interview.

Web site:

Please submit a CV and the names of three references by email to Dr. Nicholas Mitsiades at

 Baylor College of Medicine is an Affirmative Action/Equal Opportunity/Equal Access Employer.

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