Postdoctoral fellow to study zebrafish retinal development and/or chromatin organization

Postdoctoral fellow to study zebrafish retinal development and/or chromatin organization

A is available at the University of Pittsburgh to study the zebrafish retina in the following two research areas.

Polarity genes: The zebrafish retina develops from a polarized undifferentiated neuroepithelium into a functional of complex cytoarchitecture. We are interested in understanding how polarity genes regulate this remarkable developmental process as well as in how polarity genes promote photoreceptor survival in developed retina.

Chromatin organization: Growing evidence demonstrates that dynamic chromatin organization play important roles in regulating gene expression. However, the mechanisms of chromatin organization remain poorly understood. We are interested in the chromatin biology and epigenetic regulations of retinal development and aging. Our current focus is to understand how cell-type-specific chromatin organizations underlie gene expression regulations and how such chromatin organizations play critical roles in maintaining photoreceptor health.

The following papers provide further information on our research interests:

—J. Zou, X. Wang, and X. Wei (2012) Crb apical polarity proteins maintain zebrafish retinal cone mosaics via intercellular binding of their extracellular domains.

Developmental Cell. 22, 1261–1274.

—X. Yang, J. Zou, D. Hyde, L. Davidson, and X. Wei (2009) Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation.

Journal of Neuroscience. 29:11426-11440.

—J. Zou, K. Lathrop, M. Sun, X. Wei (2008) Intact RPE maintained by Nok is essential for retinal epithelial polarity and cellular patterning in zebrafish.

Journal of Neuroscience. 28(50):13684 –13695.

—X. Wei, S. Somanathan, J. Samarabandu and R. Berezney. (1999). Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles.

Journal of 146:543-558.

—X. Wei, J. Samarabandu, R.S. Devdhar, A. Siegel. R. Acharya, R. Berezney. (1998) Segregation of transcription and replication sites into higher order domains.

Science. 281:1502-1505.

We are looking for an independent, prudent, and self-motivated candidate to work on projects related to one or both of the above-mentioned research areas. Candidates should have a PhD in , , molecular biology, cell biology, or . We look forward to discussing with candidates about their research interests and career goals. Please email a cover letter, CV, and research interests to Dr. Xiangyun Wei at the following address:

Xiangyun Wei, Ph.D.


Dept. of Ophthalmology, Dept. of Developmental Biology

University of Pittsburgh School of Medicine

Pennsylvania, United States


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