Conference: Roscoff_France.EvolutionCancer.Nov2-6

*Jacques Monod Conference: **”Ecological and evolutionary perspectives in

cancer” to be held in Roscoff (Brittany), , November 2-6, 2013*
The conference is organized by Michael Hochberg (Montpellier, France) and

Paul Ewald (Louisville, ). Jacques Monod Conference website:
Cancer is a disease of opportunity, associated with clonal evolution,

expansion and competition within the body. Specifically, somatic cellular

selection and evolution are the fundamental processes leading to

malignancy, metastasis and resistance to therapies. The Jacques Monod

Conference “*Ecological and Evolutionary Perspectives in Cancer” *aims to

promote this emerging discipline by addressing some of the most important

questions about cancerogenesis. The conference will cover 3 themes:
– Interspecific patterns and processes

– Progression

– Therapies
The first theme will address the observation that infectious agents can

cause cancers. Persistent infections may promote cancer because long-term

host defensive responses induce inflammation that subsequently increases

mutation rates. Why human defensive mechanisms have not evolved to more

efficiently control or eliminate invasive cell lineages, and why do some

species with more somatic show less than expected incidences of

cancer? The second theme will evaluate the role of the tumor environment

and natural selection in explaining cancer progression. To what extent are

different cancers predictable and what are the key contributing variables?

The third theme will tackle the daunting challenge of employing

evolutionary theories to improve cancer therapies. It will seek how

preventative, curative and management therapies can be improved and even

optimized to slow or stop the emergence of resistance to chemotherapies.
*Invited speakers* and provisional titles
*AKTIPIS Athena *(San Francisco, USA): Challenges and opportunities for

evolutionary and ecological approaches to cancer
*BEERENWINKEL Nico* (Basel, ): Using next-generation sequencing

to estimate genetic tumor diversity and to inform models of

tumor evolution
*CICCARELLI Francesca* (Milano, ): Genome instability and the

evolution of cancer
*CLAIRAMBAULT Jean* (Paris, France)*: *Mathematical assessment of drug

resistance in cancer cell populations: Genetic or epigenetic phenomenon?
*CRESPI Bernard* (Burnaby, Canada): Genomic imprinting in the evolution and

development of cancer
*DELHOMMEAU François *(Paris, France): Clonal architecture in myeloid

*EWALD Paul *(Louisville, USA): Toward a unified theory of cancer
*FRIDMAN Hervé* (Paris, France): Impact of patient’s immunity and

inflammation on progression, metastasis and clinical outcome of cancers
*GATENBY Robert* (Tampa, USA)*: *Evolutionary dynamics in cancer therapy
*HAREL-BELLAN Annick* (Gif-sur-Yvette, France): Non-coding RNAs and cancer
*HENG Henry *(Detroit, USA): Genome chaos and cancer evolution
*HIBNER Urszula *(Montpellier, France): Host-pathogen interactions:

hijacking of cellular functions by the Hepatitis C virus sensitizes the

host cell to oncogenic transformation
*HOCHBERG Michael *(Montpellier, France): Optimizing preventative therapies
*KELLER Laurent (*Lausanne, Switzerland): Darwinian selection in cancer

*MAINI Philip *(Oxford, United Kingdom): Mathematical and

modeling of cancer growth and dynamics
*MALEY Carlo *(San Francisco, USA): Why we get cancer and why it has been

so hard to cure?
*OLIVIERI Isabelle *(Montpellier, France): What can we learn from

evolutionary thinking-based pesticide management for optimizing

chemotherapy protocols?
*PACHECO Jorge *(Braga, Portugal): Somatic evolution of cancer in

*PEPPER John *(Bethesda, USA): Evolutionary insights into acquired

resistance to cancer therapy, and how to avoid it
*QUINTANA-MURCI Lluis *(Paris, France): From evolutionary and population

genetics to human disease
*RADMAN Miroslav *(Paris, France): Keynote address: Biological clock in

*SAVAGE Philip *(London, United Kingdom): Why are only some cancers curable

with chemotherapy?
*SOLÉ Ricard *(Barcelona, Spain): The evolution of unstable cancer cell

*SPROUFFSKE Kathleen *(Zurich, Switzerland): Reconstructing the order of

somatic mutations in cancer progression
*STRATTON Michael *(Cambridge, United Kingdom): Sequencing the cancer

*THOMAS Frédéric *(Montpellier, France): Evolution of cancer vulnerability

among species: Peto’s paradox revisited
*TLSTY Thea *(San Francisco, USA): Identification of factors that control

the rate of malignant evolution
*TOMLINSON Ian *(Oxford, United Kingdom): Signatures and consequences of

selection in colorectal cancer genes
*WEITZMAN Jonathan* (Paris, France): What can intracellular parasites teach

us about tumorigenesis?
*ZUR HAUSEN Harald *(Heidelberg, Germany): Keynote address: Infectious

etiology of human cancers

*Registration fee (including lodging, meals and special conference dinner)*
*400 €* for PhD students
*520 €* for other participants
*Application for registration *
The total number of participants is limited to 115 and all participants are

expected to attend for the whole duration of the conference. Selection is

made on the basis of the affinity of potential participants with the topics

of the conference. Scientists and PhD Students interested in the meeting

should send:
– their curriculum vitae
– the list of their main publications for the 3 last years
– the abstract of their presentation
*to the Chairperson of the conference* ( before the

deadline. After it, the organizers will select the participants. Except in

some particular cases approved by the Chairperson, it is recommended that

all selected participants present their work during the conference, either

in poster form or by a brief in- session talk. The organizers choose the

form in which the presentations are made. No payment will be sent with the

application. Information on how and when to pay will be mailed in due time

to those selected.

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