1 July, 2013
Please find a description below. Please note that there is no registration fee for this workshop. You can register at
‘Recent Insights in Mitochondrial Evolution Applied to Health and Ageing’
Aim and description
The endosymbiosis theory envisions cytoplasmic organelles, such as mitochondria and chloroplasts, as enslaved entities whose presence is only beneficial for the cell. We now know that this view is incorrect and that conflicts, both among mitochondrial genes and between mitochondrial and nuclear genes, are prevalent. Eukaryotic cells contain multiple mitochondria, each with multiple mitochondrial genomes, and selection among these genomes can reduce cell fitness. As a consequence, during somatic growth, deleterious mitochondrial mutations can accumulate and may contribute to the development of diseases such as cancer, and aging.
Recently, novel insights in the structure and transmission of mitochondria have been gained. Originally, it was believed that mitochondria formed distinct units within the cell, with separate genomes. However, we now know that mitochondria are much more plastic, that they frequently fuse to form networks, and divide again, and that they consequently share a pool of mitochondrial genomes. This has important repercussions for the way natural selection can act among mitochondria and mitochondrial genomes within the cell. This new insight may change the way in which we can explain the accumulation of mitochondrial changes during senescence and cancerous growth.
This symposium will bring together researchers studying the molecular details of such intra-cellular processes, with medical researchers interested in mitochondria-related diseases and evolutionary biologists interested in genetic conflicts. The interaction of these three fields will be reciprocally illuminating, as so far these research fields have operated separately. Combining the different kinds of expertise will provide researchers with the necessary details to make more specific predictions about the consequences of mitochondrial evolution, both long term and during somatic growth, on diseases and aging. Evolutionary biologists will gain from a deeper understanding of the exact mechanisms underlying mitochondrial evolution, whereas molecular and medical researchers will be able to test specific predictions aimed at preventing or curing mitochondrial diseases.
This workshop will be considered a success if new collaborations are established between evolutionary biologists and medical researchers. We particularly hope to encourage collaboration among junior scientists such as PhD students, postdocs and early-career researchers. As part of the program, we will include a half-day workshop on possibilities to apply for funding to establish cross-disciplinary research programs (eg Human Frontiers Science Program grants and Cross-disciplinary Research Fellowships).
Duur Aanen, Madeleine Beekman, Marc Maas, Hans Spelbrink.
Laboratory of Genetics
Wageningen University and Research Center
Tel. +31(0)317 483144
Mobile: +31 (0)6 10327948
Fax: +31 (0)317 483146